SYS · drug.AI · V0.1 (BETA) · PATENT-PENDING
AGENTS · 0012 ACTIVE
COPILOT · HUMAN-IN-THE-LOOP
LAT · 14ms
GPU · H100 CLUSTER · 78%
STATUS · NOMINAL
drug.AI Platform · V0.1 (Beta) · Patent-Pending

A copilot for drug discovery —
not a black-box oracle.

Twelve specialized agents that hypothesize, design, dock, and critique — orchestrated by a shared reasoning graph that human scientists can inspect, veto, and steer at every step of the process.

01 · The Copilot Principle

Human-in-the-loop at every gate.

Most AI-drug-discovery platforms hand you a scored candidate list and ask you to trust it. drug.AI hands your medicinal chemists a research partner they can inspect, question, and steer — because in rare oncology, "trust me" is not an acceptable answer.

Copilot Guarantee
0%
Human-reviewed candidates. No prediction ever ships without a scientist's sign-off.
12Autonomous agents
6Human review gates
0Un-validated candidates
◉ drug.AI · Agentic Copilot
Transparent. Steerable.
Wet-lab validated.
  • Every candidate carries a full provenance chain — every score, every rejection, every human override preserved and queryable.
  • Scientists inspect the reasoning graph and veto agents in real time. Overrides become training signal for the next cycle.
  • Agents argue with each other. When they disagree, the debate is surfaced to a human — not resolved silently.
  • Efficacy is measured against wet-lab ground truth on every program. Predictions never ship un-validated.
  • Compliance-by-design: regulatory readiness baked into every model, dataset, and experimental record from day one.
  • Modular agent architecture — when something fails, you know exactly which agent, which decision, and why.
VS
⚠ Black-Box AI Platforms
Opaque predictions.
Unclear efficacy.
  • Ranked candidate list handed off — no way to inspect why a molecule was chosen or why others were dropped.
  • No mechanism to override or steer without retraining the whole model. Chemist intuition is discarded.
  • One monolithic model. When it's wrong, you can't tell which sub-component failed or how to fix it.
  • Retrospective benchmarks over prospective validation — the paper looks great; the clinic often doesn't.
  • Regulatory trail is an afterthought — bolted on before IND, not designed in from day zero.
  • Trust the black box. Or don't. Either way, you're on your own.
THE COPILOT LOOP Agent Proposes candidate + rationale Reasoning Graph provenance + debate Human Reviews approve · veto · steer Wet Lab validates efficacy EVERY OVERRIDE + EVERY ASSAY RESULT RETRAINS THE AGENTS

Every prediction is a proposal. Every proposal has a debate. Every decision has a human sign-off. That's the difference.

02 · Multi-Agent Orchestration

The agents.

Each agent owns a stage of the discovery loop. They communicate through a shared knowledge graph — passing structured hypotheses, not natural language, so nothing gets lost in translation and every step is inspectable.

ACTIVE
A · 01
Target Hunter
Mines multi-omics + literature graphs to nominate druggable targets ranked by disease relevance and tractability.
ACTIVE
A · 02
Structure Solver
Runs equivariant folding + cryo-EM refinement to resolve target conformations and cryptic binding pockets.
ACTIVE
A · 03
Molecule Composer
Generative diffusion over chemical space — designs novel scaffolds conditioned on pocket geometry and ADMET priors.
ACTIVE
A · 04
Critic & Ranker
Adversarially scores candidates on binding, selectivity, synthesizability, and clinical translatability — proposes the next batch.
ACTIVE
A · 05
Retrosynthesis Planner
Plans multi-step syntheses in seconds — flags routes with reagent hazards, low-yield steps, or missing precedents.
ACTIVE
A · 06
ADMET Oracle
Predicts pharmacokinetics, toxicity, hERG liability, and human clearance — trained on decades of proprietary in-vivo data.
ACTIVE
A · 07
Selectivity Scout
Screens kinome-wide (or GPCR-wide, etc.) — surfaces off-targets before wet-lab dollars are spent.
ACTIVE
A · 08
Portfolio Strategist
Balances the pipeline — weighs commercial potential, IP whitespace, and technical risk to prioritize the next program.

+ 4 more specialist agents (Assay Designer, Formulation Chemist, Patent Analyst, Clinical Translator).

03 · Live Console

Watch a discovery cycle unfold.

A real run trace from cycle #4472 — target nomination through candidate promotion, in ~17 elapsed days compressed here to a few seconds.

SILOAM :: agent-console :: live-run #4472
04 · Generative Design

Atoms placed by diffusion,
not filtered from libraries.

Our composer grows molecules atom-by-atom inside the target pocket — steered by binding potential, ADMET priors, and synthesizability constraints all at once. This isn't virtual screening. It's de novo design.

Drag the molecule to rotate. Hover any atom to inspect.

05 · Reasoning Graph

Agents that argue,
not just answer.

Every decision traces back through a graph of competing hypotheses. Human scientists inspect, veto, and inject constraints — the system learns from every intervention.

This isn't a black-box oracle. It's a transparent partner that shows its work at every step.

06 · System Architecture

How the pieces fit together.

DATA LAYER AGENT MESH REASONING GRAPH HUMAN + LAB Omics + Clinical PDB + AF3 ChEMBL + Prop. Wet-Lab Assays Literature Graph Target Hunter Structure Solver Composer Critic + ADMET Retrosynthesis Shared Hypothesis Graph · versioned · queryable · human-readable Human Scientists Autonomous Wet Lab Clinical Translation FEEDBACK · NIGHTLY RETRAIN
07 · Capabilities

What the platform does for you.

C · 01
De Novo Design
Diffusion over 3D atomic coordinates — molecules grown atom-by-atom inside the pocket, not filtered from libraries.
C · 02
Cryptic Pocket Discovery
MD ensembles + geometric deep learning reveal allosteric sites invisible to static crystallography.
C · 03
Multi-Objective Optimization
Pareto-optimal search across potency, selectivity, ADMET, and IP whitespace — steered by medicinal chemists.
C · 04
Autonomous Wet Lab
Selected candidates dispatched to robotic synthesis + biophysical assays. Results retrain the agents overnight.
C · 05
Explainable Decisions
Every candidate carries a provenance chain — every score, every rejection, every human intervention preserved.
C · 06
Clinical Translation
Preclinical PK/PD modeled from human-derived organoid data — de-risking the leap from bench to first-in-human trials.
08 · Partner With Us

Want to put drug.AI
on your hardest rare-oncology target?